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Increased doses of tapentadol ought to be anticipated to be barely stronger than predicted by linear capabilities of the earlier dose-response relation. Tapentadol is an agonist of the μ-opioid receptor and a norepinephrine reuptake inhibitor . Analgesia happens inside 32 minutes after oral administration, and lasts for 4–6 hours. It is eighteen occasions much less potent than morphine when it comes to binding to human mu-opioid receptors in in vitro research on human tissue. In vivo, only 32% of an oral dose of tapentadol will survive first cross metabolism and proceed to the bloodstream to produce its results on the central and peripheral nervous systems of the patient.