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Increased doses of tapentadol should be anticipated to be slightly stronger than predicted by linear capabilities of the earlier dose-response relation. Tapentadol is an agonist of the μ-opioid receptor and a norepinephrine reuptake inhibitor . Analgesia occurs inside 32 minutes after oral administration, and lasts for 4–6 hours. It is 18 instances less potent than morphine in terms of binding to human mu-opioid receptors in in vitro research on human tissue. In vivo, only 32% of an oral dose of tapentadol will survive first cross metabolism and proceed to the bloodstream to provide its results on the central and peripheral nervous techniques of the affected person.