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Generic NameModafinilDrugBank Accession NumberDB00745BackgroundModafinil is a stimulant drug marketed as a 'wakefulness selling agent' and is among the stimulants used within the treatment of narcolepsy. The exact mechanism of motion is unclear, though in vitro research have proven it to inhibit the reuptake of dopamine by binding to the dopamine reuptake pump, and lead to a rise in extracellular dopamine. In people, modafinil produces psychoactive and euphoric results, alterations in mood, notion, considering, and emotions typical of other CNS stimulants. In in vitro binding studies, modafinil binds to the dopamine reuptake website and causes an increase in extracellular dopamine, can you buy xanax online but no improve in dopamine release.
bMore than 50% of caffeine group reported symptoms of nervousness, excitation, stomach pain, dry mouth, tremor, nausea, and jitteriness. More than 50% of amphetamine group reported symptoms of excitation, happiness, and dry mouth.
Other noticed high-dose results in clinical studies have included anxiety, irritability, aggressiveness, confusion, nervousness, tremor, palpitations, sleep disturbances, nausea, diarrhea, and decreased prothrombin time. "Modafinil is nicely tolerated, with no proof of tolerance developing throughout 40 weeks of remedy." from "Long-term efficacy and safety of modafinil (PROVIGIL ®) for the therapy of extreme daytime sleepiness related to narcolepsy", Mitler 2000.
Interaction with P-Glycoprotein An in vitro examine demonstrated that armodafinil is a substrate of P-glycoprotein. Concomitant administration of armodafinil with quetiapine reduced the systemic exposure of quetiapine. There was no apparent change within the elimination fee of ethinyl estradiol. The optical enantiomers of modafinil have comparable pharmacological actions in animals.
Generic NameModafinilDrugBank Accession NumberDB00745BackgroundModafinil is a stimulant drug marketed as a 'wakefulness selling agent' and is among the stimulants used within the treatment of narcolepsy. The exact mechanism of motion is unclear, though in vitro research have proven it to inhibit the reuptake of dopamine by binding to the dopamine reuptake pump, and lead to a rise in extracellular dopamine. In people, modafinil produces psychoactive and euphoric results, alterations in mood, notion, considering, and emotions typical of other CNS stimulants. In in vitro binding studies, modafinil binds to the dopamine reuptake website and causes an increase in extracellular dopamine, can you buy xanax online but no improve in dopamine release.bMore than 50% of caffeine group reported symptoms of nervousness, excitation, stomach pain, dry mouth, tremor, nausea, and jitteriness. More than 50% of amphetamine group reported symptoms of excitation, happiness, and dry mouth.
Other noticed high-dose results in clinical studies have included anxiety, irritability, aggressiveness, confusion, nervousness, tremor, palpitations, sleep disturbances, nausea, diarrhea, and decreased prothrombin time. "Modafinil is nicely tolerated, with no proof of tolerance developing throughout 40 weeks of remedy." from "Long-term efficacy and safety of modafinil (PROVIGIL ®) for the therapy of extreme daytime sleepiness related to narcolepsy", Mitler 2000.
Interaction with P-Glycoprotein An in vitro examine demonstrated that armodafinil is a substrate of P-glycoprotein. Concomitant administration of armodafinil with quetiapine reduced the systemic exposure of quetiapine. There was no apparent change within the elimination fee of ethinyl estradiol. The optical enantiomers of modafinil have comparable pharmacological actions in animals.